This is an easy one. Run OTRS within a VM appliance ( which every flavor you know best but VMware has the tools to automate most if this natively.) and perform SnapShots as often as your RPO/RTO requires. Make sure to delete old one and only keep a few "current" version (weeks worth is you are doing hourly/daily snaps). Put these into a SAN storage where that is backed up too and best would to rep them to a remote DR facility. You can restore and entire system from a snap in VMware in minutes even if you have to remove and place new hardware as the system is pretty hardware agnostic.