[otrs] Mail response from: header domain based on incoming from: domain?

Let me apologize first if this question has already been asked, but I have not discovered it: Is it possible to set mail responses "from:" headers to be the same as that of the incoming from: domain? Our support department handles support for hundreds of domain.com addresses. It would be ideal if we could tailor each OTRS support request that comes in as, say, "support@domain12.com" to be answered as csrXX@domain12.com in the response header. How would I do this? Thanks in advance.