Other very viable option, as posted earlier in this thread, is to run OTRS on a tertiary domain. 
 
LQ


From: otrs-bounces@otrs.org [mailto:otrs-bounces@otrs.org] On Behalf Of CARNINO Daniele (FIAT ITEM)
Sent: Tuesday, February 10, 2009 5:29 AM
To: 'User questions and discussions about OTRS.'
Subject: [otrs] R: Latching onto Exchange

Don't waste time considering this option.
Seriously.
I've had the same problem this summer, and I have tried to implement Openchange protocol.
I have succeeded in connecting to mailboxes and  in downloading messages on a local mailbox.
I've also piped the mails collected through Postmaster script onto OTRS.
I did a LOT of work but the issues remains simply too much to use this solution in a production environment.
So definitely go and ask to enable POP3 or IMAP on per-mailbox basis: this is the only reliable way, now.
If you really need it, your mail admins should (and could) do this.
Period. 

Ciao, d.