On Oct 10, 2011, at 9:34 , Andy Wodfer wrote:

Is there a way I can block or reject emails in OTRS and also not sending out automatic replies to certain specified addresses? We have some problems with some newsletter-junkmails and some endless loops that are filling up our RAW inbox ...

You need a Postmaster Filter with 

Match: EMAILADDRESS:mail@domain.com
Set: X-OTRS-Ignore yes
Stop After Match yes

///shawn