Yes, with OTRS this can be done (easy) !
In OTRS you need to define different system e-mail addresses and different queues per domain. In the definition of the queue, you assign the "system"(reply) address.
I'm new enough to OTRS that this is my first time being bold enough to offer advice... so take it with a grain of salt :-) But, FYI, I think this implies that you're OK with having different queues for the different sender's domains. Incoming emails are sorted (with lots of flexibility/smarts) into queues. Sender domain could be one of the criteria for queue assignment. Replies, status emails, etc. from those queues can have any address you want - but only one outgoing email address per queue. So you'd have to sort different incoming domains to different queues to have their replies have different addresses. This may be fine (probably is, in fact) but I wanted to mention it. Mike Morris The Music Place 1617 Willowhurst Avenue San Jose, CA 95125 (408) 445-ARTS (2787) ------------------------------------ Your Free Quote: We are not afraid to entrust the American people with unpleasant facts, foreign ideas, alien philosophies, and competitive values. For a nation that is afraid to let its people judge the truth and falsehood in an open market is a nation that is afraid of its people. - John F. Kennedy ------------------------------------