Hi list.

at following url

https://scubarda.wordpress.com/2017/01/21/fix-otrs-compatibility-problems-with-internet-explorer-via-active-directory-gpo/

you can find a blog post I wrote on how to fix compatibility problems with OTRS while using Microsoft Internet Explorer.

Tested on:

Active Directory Win2008R2 environment
OTRS 4
Internet Explorer 11

Hope this can be useful

Giovanni