[otrs] Auto Responses <-> Queue Does not work

Dear Colleagues, I am finding some difficulty with the configuring and Customization of the Auto Responses <-> Queue so that when a customer sends a mail, the system automatically replies. I am a new user of the OTRS and trying to use it for my company but am finding some problems. I am using the default settings and i am trying it on my laptop to configure before setting it up. Please help me. Thanks.