Hi Tony,
Am using CentOS 5; Oracle 10g and Apache...otrs 2.4.5 is working "Perfectly Well" on my system; am actually running multiple instances! I installed the following modules using cpan on my system:
=>CGI DBI Date::Pcalc DBD::Oracle Digest::MD5 LWP::UserAgent MIME::Base64 MIME::Tools Mail::Internet Net::DNS Net::POP3 Net::LDAP Net::SMTP Authen::SASL GD GD::Text GD::Graph GD::Graph::lines GD::Text::Align XML::Parser PDF::API2 Compress::Zlib Apache2::Reload=>

=>Note:! I prefer to use the source tarball as opposed to the rpm

Michael