I configured OTRS to send mail via SMTP relay/smarthost, the autoreply function is able to send mail But when I try to send an email as an answer to a ticket it comes with the following error : Fout: Can't connect to smtp.office.firstfind.nl: Invalid argument! Terug traceren: ERROR: OTRS-CGI-10 Perl: 5.6.1 OS: linux Time: Wed Aug 18 11:45:49 2004 Message: Can't connect to smtp.office.firstfind.nl: Invalid argument! Traceback (4088): Module: Kernel::System::Email::SMTP::Send (v1.6) Line: 152 Module: Kernel::System::Email::Send (v1.3) Line: 108 Module: Kernel::System::Ticket::SendArticle::SendArticle (v1.15) Line: 185 Module: Kernel::Modules::AgentCompose::SendEmail (v1.58.2.1) Line: 376 Module: Kernel::Modules::AgentCompose::Run (v1.58.2.1) Line: 78 Module: Apache::ROOT::otrs::index_2epl::handler (v1.66) Line: 687 Module: (eval) (v2.01) Line: 143 Module: Apache::Registry::handler (v2.01) Line: 14 Thanks in advance, Jeroen Bosch